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We review papers, explore ideas and write pedagogical articles & deep dives on areas that excite us!

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  • Are we there yet with precision medicines? Or are we making medicines less precise?

    We are called to be architects of the future, not its victims. The challenge is to make the world work for 100% of humanity in the shortest possible time, with spontaneous cooperation, and without ecological damage or disadvantage of anyone. ~ R. Buckminster Fuller The human body is made from tens of trillions of cells…

  • We Forgot to Teach AI Agents to Be Wrong on Purpose

    What old logic papers know about the scientific process that challenges your AI scientist If you are a scientist like I am, or a clinician, let me portray a likely scenario. You are excited about your AI Scientist / Research Agent. So it set it up for research task. Your agent reads four hundred papers…

  • To dose, or not to dose: that is the question

    How China’s Investigator-Initiated Pathway Is Rewriting the Validation Trajectory for Cell/Tissue Targeted Medicines A perfect storm In September 2025, the New England Journal of Medicine published as Correspondence the first clinical data that would have seemed implausible five years ago. Five patients with refractory systemic lupus erythematosus had received an intravenous infusion containing messenger RNA…